From Toronto

Take the Queen Elizabeth Way west to Highway 403 west (Hamilton / Brantford) or take 401 west to Highway 403 west or take Highway 407 west (toll road) to Highway 403 west. At the Brant Street overpass, stay in the right lane and exit onto 403 west, continue along 403 west past downtown Hamilton, ascending the escarpment. Exit 403 onto Highway 6 south. Turn left onto Airport Terminal Road.

From Buffalo, New York

Take the Queen Elizabeth Way west to Hamilton. Exit Highway 20 / Centennial Parkway and continue on Highway 20 ascending the escarpment. Turn right on Mud Street and follow Mud Street west to the Lincoln Alexander Parkway (south). Exit onto Highway 6 / Upper James Street (turn left at intersection from exit ramp) and turn right onto Airport Road.